Search on: NEUTRAL PROTEINASE, CALCIUM-DEPENDENT 
Descriptors Found: 1
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Descriptor English:   Calpain 
Descriptor Spanish:   Calpaína 
Descriptor Portuguese:   Calpaína 
Synonyms English:   Ca2+-Activated Protease
Calcium-Activated Neutral Proteinase
Calcium-Activated Protease
Calcium-Dependent Neutral Protease
Calpain I
Calpain II
Desminase
Ca2+ Activated Protease
Calcium Activated Neutral Protease
Calcium Activated Neutral Proteinase
Calcium Activated Protease
Calcium Dependent Neutral Protease
Calcium Dependent Neutral Proteinase
Neutral Protease, Calcium-Activated
Neutral Protease, Calcium-Dependent
Neutral Proteinase, Calcium-Activated
Neutral Proteinase, Calcium-Dependent
Protease, Ca2+-Activated
Protease, Calcium-Activated
Protease, Calcium-Activated Neutral
Protease, Calcium-Dependent Neutral
Proteinase, Calcium-Activated Neutral
Proteinase, Calcium-Dependent Neutral
Calcium-Activated Neutral Protease
Calcium-Dependent Neutral Proteinase  
Tree Number:   D08.811.277.656.262.500.120
D08.811.277.656.300.200.120
Definition English:   Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4. 
Indexing Annotation English:   /biosyn /physiol permitted
History Note English:   86 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   23227 
Unique Identifier:   D002154 

Occurrence in VHL: 		 

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